Pol II Alpha: A Key Player in Gene Expression and DNA Replication

Target Name: RNA polymerase II complex

NCBI ID: P28902

RNA polymerase II complex

Other Name(s): Pol II

Pol II Alpha: A Key Player in Gene Expression and DNA Replication

RNA polymerase II complex (Pol II) is a protein complex that plays a critical role in gene expression and DNA replication. It is composed of multiple subunits that work together to ensure the accuracy and efficiency of DNA replication. One of the subunits, known as Pol II alpha, is a key player in the process of transcription, where RNA polymerase II complex uses the information in DNA to create an RNA molecule.

Pol II alpha is a 25 kDa protein that consists of 11 subunits. It has a characteristic alpha-helices structure that allows it to interact with the template DNA and guide the RNA polymerase II complex along the DNA strand. It is also able to recognize specific sequences within the DNA that are essential for efficient transcription.

One of the key features of Pol II alpha is its ability to form a stable complex with the DNA. This stability is important for efficient transcription because it allows the RNA polymerase II complex to access the template DNA and start the transcription process. Additionally, the stability of the Pol II complex allows it to withstand various conditions, such as high temperatures and low concentrations of DNA.

Another key feature of Pol II alpha is its role in the regulation of gene expression. It is able to interact with other proteins that are involved in gene expression, such as RNA factor 2 (RF2) and the protein silencer-interacting protein ( SPI). These interactions allow Pol II alpha to regulate the activity of these other proteins and ultimately control gene expression.

Pol II alpha is also involved in DNA replication. As the Pol II complex is responsible for transcription, it is also involved in the process of DNA replication. It is able to recognize specific sequences within the DNA that are essential for efficient replication and is able to guide the RNA polymerase II complex along the DNA strand to ensure accurate replication of the DNA template.

In conclusion, RNA polymerase II complex (Pol II) is a protein complex that plays a critical role in gene expression and DNA replication. It is composed of multiple subunits, including the alpha subunit, which is responsible for the interaction with DNA and the regulation of gene expression. Pol II alpha is able to form a stable complex with the DNA, withstand various conditions, and participate in the regulation of gene expression and DNA replication. Therefore, it is a potential drug target and biomarker.

Protein Name: RNA Polymerase II Complex

The "RNA polymerase II complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNA polymerase II complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets